- Safety & Security Systems & Consultants, Holly Springs
- Satellite Dish Antennas & Equipment Dealers, Holly Springs
- School - Christian, Holly Springs
- Secondary Schools, Holly Springs
- Security Alarm Systems - Home & Business, Holly Springs
- Security Control Systems & Monitoring, Holly Springs - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Guard & Patrol Service, Holly Springs - Bodyguard, Guard Dogs, Etc
- Security Services, Holly Springs
- Septic Tanks & Septic Systems Contractors, Holly Springs - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sheriff's Department, Holly Springs
- Shopping & Shopping Services, Holly Springs
- Social Services & Welfare, Holly Springs
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- Special Education & Care, Holly Springs
- Specialty Stores, Holly Springs
- Speech & Hearing Specialists, Holly Springs
- Speech Pathologists, Holly Springs - Speech & Language Therapy
- Sporting Goods Stores, Holly Springs
- Staffing & Support Services, Holly Springs
- State Government, Holly Springs
- State Parks, Holly Springs
- Substance Abuse Clinics, Holly Springs - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Support Services, Holly Springs
- Surveyor Services, Holly Springs - Surveying Service
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